Effect of Serotonin Transporter 5-HTTLPR Polymorphism on. Effect of Serotonin Transporter 5-HTTLPR Polymorphism on.
Genetic polymorphisms also occur frequently in other transmembrane transport systems including the multidrug resistance proteins (MRPs, ABCC2). The aim of this research was to investigate the possible association of ABCC2 gene polymorphisms G1249A in exon 10 and C24T in exon 1 with the development of drug resistance. This cross-sectional study is a part of ongoing pharmacogenomic …. Genetic polymorphisms affecting the activity and/or the expression of cytochromes P450 or UGT isozymes and membrane drug transport proteins are highlighted and include such examples as the association of neurotoxicity with efavirenz, nephrotoxicity with tenofovir, hepatotoxicity with nevirapine, and hyperbilirubinemia with indinavir and atazanavir. Mechanisms of drug resistance conferred by.
cDNA sequence, NM_021075.3. SNP, single nucleotide polymorphism. Application of SNP positions and their allele frequency data in genes related to drug response will be very important for population-based pharmacogenetic studies as well as for the development … The cytochrome P450 superfamily (CYP450) in humans is formed by 57 functional monooxygenases critical for the metabolism of numerous endogenous and exogenous compounds. The superfamily is organized into 18 families and 44 subfamilies. CYP nomenclature is based on the identity of amino acids. The most important functions of the CYP450 are
Genetic polymorphism has great influences on the improvement of cattle traits. The polymorphism of the same gene family will greatly change the growth traits of cattle, such as the pleomorphic adenoma gene (PLAG) family. Many studies have shown that the PLAG family proteins are the transcription regulators of nuclear protein, which mainly regulates the expression of many important genes in the Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors. Blood 91: 1749 – 56 Medline
Therefore, in the present study, the relationship between genetic polymorphism of serotonin transporter in smoking behaviour is reviewed considering the interactive effect of genetic factors. [Watanabe M. A. E., Nunes S. O. V., Amarante M. K., Guembarovski R. L., Oda J. M. M., Lima K. W. A. and Fungaro M. H. P. 2011 Genetic polymorphism of serotonin transporter 5-HTTLPR: involvement …. Genetic polymorphism of these molecules and other membrane transport proteins that regulate cisplatin accumulation may influence cisplatin- related nephrotoxic outcome. Variations of DNA repair enzymes, e.g., ERCC1 , eIF3, MMS 19L , and metabolic enzymes involved in platinum detoxification, e.g., GSTT1 , GSTM1 may also have important role in the generation of nephrotoxicity..
“Expression of P-glycoprotein in Human Placenta Relation”.
Particularly in breast cancer, genetic polymorphisms of proteins involved in drug transport or metabolism have been shown to affect the efficacy of agents such as tamoxifen, taxanes or aromatase inhibitors [7, 33, 34]..
genetic polymorphisms, eg drug metabolising enzymes (cytochrome P450 (CYP450) and UDP-glucuronosyltransferases (UGTs) and transporters (ABCB1). Individuals can. between genetic factors and postoperative sufentanil therapy. Keywords: Pharmacogenetics, polymorphism, sufentanil, visual analogue scale (VAS), μ-opioid receptor gene (OPRM1). Particularly in breast cancer, genetic polymorphisms of proteins involved in drug transport or metabolism have been shown to affect the efficacy of agents such as tamoxifen, taxanes or aromatase inhibitors [7, 33, 34]..
Schematic view of the polymorphisms associated with the serotonin transporter gene. Three common polymorphisms associated with the serotonin transporter have been described. Abstract. Background and purpose: The major drug-metabolizing enzymes for the oxidation of oxycodone are CYP2D6 and CYP3A. A high interindividual variability in the activity of these enzymes because of genetic polymorphisms and/or drug–drug interactions is well established.